(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity
نویسندگان
چکیده
منابع مشابه
Cannabinoids inhibit cellular respiration of human oral cancer cells.
BACKGROUND AND PURPOSE The primary cannabinoids, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) are known to disturb the mitochondrial function and possess antitumor activities. These observations prompted us to investigate their effects on the mitochondrial O(2) consumption in human oral cancer cells (Tu183). This epithelial cell line overexpresse...
متن کاملMitochondria and neuronal activity.
Mitochondria are central for various cellular processes that include ATP production, intracellular Ca(2+) signaling, and generation of reactive oxygen species. Neurons critically depend on mitochondrial function to establish membrane excitability and to execute the complex processes of neurotransmission and plasticity. While much information about mitochondrial properties is available from stud...
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Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. ...
متن کاملInvited Review Mitochondria and neuronal activity
Kann O, Kovács R. Mitochondria and neuronal activity. Am J Physiol Cell Physiol 292: C641–C657, 2007. First published November 8, 2006; doi:10.1152/ajpcell.00222.2006.—Mitochondria are central for various cellular processes that include ATP production, intracellular Ca signaling, and generation of reactive oxygen species. Neurons critically depend on mitochondrial function to establish membrane...
متن کاملCannabinoids inhibit the respiration of human sperm.
OBJECTIVE To investigate the effects of the psychotropic compounds Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) on sperm mitochondrial O(2) consumption (respiration). SETTING State University of New York Upstate Medical University, Syracuse, New York. PATIENT(S) Forty-one men who visited the andrology laboratory for fertility evaluation. IN...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2017
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2016.12.020